Dados do Resumo

Título

Profile of Japanese-Brazilian breast cancer patients treated at a Brazilian cancer center.

Introdução

Breast cancer/BC is the most common cancer among Japanese women in Japan and abroad. Japan has a lower incidence of BC and a better survival rate than the West. Japanese women living in the West for a decade or more have an 80.0% higher risk of developing BC in the United States of America. The difference in incidence, mortality and evolution may be due to multiple factors such as geographical variations, racial/ethnic patterns, genetics, lifestyle, socio-economic status, secondary prevention.

Objetivo

To identify the profile of Japanese-Brazilian breast cancer patients treated at a Brazilian cancer center.

Métodos

This is a retrospective cross-sectional study based on a survey of the medical records of patients with initial breast cancer of first-generation Japanese origin, born in Brazil and treated at the AC Camargo Cancer Center. Women diagnosed with BC between 1988 and 2023 at the A.C. Camargo Cancer Center were identified by their Japanese surnames; the generation was validated by analyzing the names of their parents and public immigration records. Those whose evidence of their Japanese origin could not be validated were excluded. These data were part of a departmental database; electronic medical records were used for follow-up updates. In order to assess a possible association between two qualitative variables, Fisher's exact test or the chi-squared test will be applied. To compare quantitative variables between two independent groups, the Mann-Whitney non-parametric U-test or T-test will be used. The significance level adopted will be 5.0%. Ethical approval nº. 3560/24.

Resultados

A total of 521 cases of BC in Japanese-Brazilian women were analyzed. The median age was 57; 42.1% were aged 60 or over. Around 64.0% were menopausal; 78.7% did not use contraceptives and 79.7% did not undergo hormone replacement. The median body mass index was 24.0kg/m2; 39.5% were overweight or obese. Almost 90.0% had some finding on mammography/MMG at diagnosis (39.5% microcalcifications) and 86.9% on ultrasound/USG (81.3% nodule). Histological type was invasive ductal in 57.2% and exclusive in situ in 19.9%. Histological grade 2 were 42.6%. The most common immunophenotype was luminal A (53.4%); Triple Negative 6.9%. More than 62.0% were early stage. Breast-conserving surgery was performed in 56.3% and sentinel lymph node analysis in 82.7%. Only 6.5% underwent neoadjuvant chemotherapy and 67.1%, radiotherapy. Of the 3.4% known recurrences, most were in the axilla, breast skin or contralateral breast. Of the 9.1% of metastases, the majority were liver, followed by bone and lung.

Conclusões

In this study, we describe a sample of Japanese-Brazilian women, mostly older, in menopause, with no history of contraceptive use or hormone replacement therapy. Although more than 60.0% had early disease, almost 80.0% had MMG or USG findings. Around 78.0% were luminal and most were treated with conservative upfront surgery, radiotherapy and hormone therapy.

Palavras Chave

Breast cancer; japanese women; cancer treatment