Dados do Resumo

Título

EFFICACY OF USING TOOLS TO PREDICT ANTINEOPLASTIC-INDUCED TOXICITY IN ELDERLY PATIENTS

Introdução

Cancer refers to a proliferative disease with metastatic potential and death in many cases. Systemic therapy consists of the administration of drugs to stop cell growth and prevent the progression of the disease. However, these drugs carry a significant risk of toxicity, especially in the elderly population, a heterogeneous and multi-comorbid group of patients.

Objetivo

To evaluate in the literature which scales are used to predict the risk of chemotherapy-induced toxicity in elderly patients.

Métodos

This is a rapid review of articles available on the Medical Literature Analysis and Retrieval System Online (PubMed) database, where all the stages of a systematic review were carried out, accelerating the process of searching for evidence, using the descriptors: “Neoplasm”, “aged”, “80 and over”, “geriatrics”, “geriatric assessment”, “antineoplastic agents”, “chemotherapy”, “toxicity”, “adverse event”, with no limitations as to time of publication, with a filter for systematic reviews and meta-analysis.

Resultados

Thirteen articles were retrieved, with a prevalence of French studies published between 2015 and 2024. The scales most used to assess the degree of toxicity were: Comprehensive geriatric assessment (CGA), Charlson Comorbidity Index (CCI) and Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH). From the studies analyzed, the scales performed well in predicting worsening clinical performance, although further studies assessing the quality of life of the patients in question are recommended.

Conclusões

The use of scales is effective in evaluating the clinical performance of elderly patients undergoing chemotherapy, and their application can prevent such patients from developing more critical toxicity and having more tolerance to the proposed treatment.

Palavras Chave

Antineoplastic; Aged; Toxicity