Dados do Resumo

Título

PREVALENCE OF HUMAN PAPILLOMAVIRUS IN RECTAL TUMORS IN PATIENTS TREATED AT A PUBLIC REFERENCE CANCER CENTER IN MANAUS, AMAZONAS, BRAZIL

Introdução

The Human Papillomavirus (HPV) is a leading cause of anogenital cancers and the most prevalent sexually transmitted infection globally. Most sexually active individuals will be exposed to HPV at least once. Early diagnosis is key, as early-stage detection leads to high cure rates. HPV infects cutaneous and mucosal epithelia, with a notable link to anal cancer, though its role in rectal carcinogenesis remains controversial.

Objetivo

The aim of the present study was to analyze the clinical and epidemiological characteristics of individuals with a confirmed diagnosis of rectal cancer and the prevalence of HPV infection.

Métodos

Between July 2023 and July 2024, 72 participants were included in the study, along with 33 biological samples from rectal cancer tumors. HPV detection and genotyping were carried out in two stages: conventional PCR using generic PGMY09/11 primers and qPCR targeting the E7 region of HPV types 16 and 18. This investigation was conducted at a public reference cancer center hospital in Manaus, Amazonas—Brazil The project was approved by the Ethics Committee – Approval Number: 5.702.723.

Resultados

The mean age of patients at the time of diagnosis was 59.2 years ± SD 12.8, ranging from 28 to 87 years old, with women predominating at 58%, and 71.9% of patients being over fifty years old. Most of the patients (58,5%) came from rural areas of the Amazonas State. Thirty-three percent of the patients were smokers or ex-smokers, and 38,9 % were alcoholics. The most common behavioral factors were red meat 58 %. HPV infection was observed in 18% (6/33) of cases. HPV16 was detected in 5 patients (83,4%). Other HPV types detected included HPV18 16,7 % (1/6).

Conclusões

Although the risk factors for rectal carcinogenesis align with those described in the literature, our sample did not demonstrate a clear link between HPV and the development of rectal cancer. In Amazonas, HPV prevalence was higher in the rural population. Overall, HPV is more prevalent in areas with limited access to healthcare services.

Financiador do resumo

FAPEAM – Programa PAIC 23/24; EDITAL N. 002/2021 - PROGRAMA AMAZÔNIDAS; RESOLUÇÃO N. 002/2008, 007/2018 e 005/2019 - PRÓ-ESTADO REDE GENÔMICA DE VIGILÂNCIA EM SAÚDE: OTIMIZAÇÃO DA ASSISTÊNCIA E PESQUISA NO ESTADO DO AMAZONAS – REGESAM

Palavras Chave

HPV; Prevalence; RECTAL CANCER