Dados do Trabalho

Name: Next Frontiers to Cure Cancer
Start: 2023-09-15
End: 2023-09-16
Location: Expo Center Norte (Pavilhão Amarelo)

Título

MORTALITY TREND ANALYSIS OF HEAD AND NECK CANCER IN BRAZILIAN POPULATION FROM 2012 TO 2021

Introdução

The burden of cancer is increasing worldwide and it is worse for low- and middle-income countries. Behavioral and lifestyle changes have contributed to this increase. The incidence of head and neck squamous cell cancer (HNSCC) associated with HPV-infection is still rising. The regular consumption of alcohol and tobacco are the main risk factors for HNSCC and men are usually more affected than women. The late stage at diagnosis is an important reason for poorer survival.

Objetivo

This study aimed to analyze the HNSCC mortality trends in Brazil, by age, sex and skin color in the period of 2012 to 2021.

Métodos

We performed a trend analysis using the Joinpoint Regression Program - Version 5.0.2 and calculated the annual percent change (APC) of rates by age group, sex and skin color. P<0.05 was considered. Data were extracted from TabNetWin32 3.0 Datasus and the International Classification of Diseases for Oncology (ICD-O) included are: laryngeal cancer (C32) - group 1; hypopharyngeal cancer (C13) - group 2; oropharyngeal cancer (C10), base of tongue (C01.9), tonsil (C09) - group 3 and oral cavity cancer: retromolar trigone (C06.2), floor of mouth (C04), ⅔ tongue (C02), buccal mucosa (C06) and hard palate (C05) - group 4.

Resultados

All groups, have presented a trend towards an increase in the mortality rate in the age group above 60 years, more notably in group 3, between 60-69 years: APC 2.98 (p-value < 0.001). In all groups, there is a trend towards a reduction in the mortality rate in the age group below 60 years, more notably in group 3, between 30-39: APC -8 (p-value 0.018). The white color tended towards a decrease in the mortality rate in all groups 1, 2 and 3. Group 1: APC -1.68 (p-value < 0.001); group 2: APC -2.08 (p-value < 0.003) and group 3: -1.35 (p-value < 0.001), as opposed to brown skin color, which showed an increase. Group 1: APC 2.28 (p-value <0.01), group 2: APC 3.22 (p-value 0.004) and group 3: APC 1.74 (p-value < 0.001). In group 4, there was a trend towards an increase in the mortality rate among women, between 2015 and 2021: APC 1.74 (p-value 0.019); male showed a downward trend in the same period, with APC -0.57 (p-value 0.022).

Conclusões

The mortality rates tended to increase, for all groups between age 50-59 the opposite happening between age 40-60. Considering the variable sex, there was found a difference with significance statistically for group 4 (Oral Cavity) in which was seen an tendency to increase in mortality rate for women and decrease for men. The mortality rate of HNSCC tended to decrease white people, and to increase in black people with light skin.